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| 1530 |
| | | Atahualpa defeats and kills his half-brother Huáscar, thus winning control of the entire Inca empire | |
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| 1530 |
| | | German botanist Otto Brunfels publishes Living images of plants, the first serious work of natural history with printed illustrations | |
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| 1530 |
| | | The first Mughal emperor, Babur, dies in India and is succeeded by his son, Humayun | |
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| 1531 |
| | | The Aztec Virgin of Guadalupe appears to an Indian near Mexico City and tells him she is 'one of his kind' | |
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| 1531 |
| | | The Protestant princes of Germany form the defensive League of Schmalkalden | |
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| 1531 |
| | | Zwingli is killed at Kappel in a battle between Protestant and Catholic cantons | |
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| 1531 |
| | | Francisco Pizarro leads 168 men, with about 30 horses, into the territory of the Inca empire | |
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| 1532 |
| | | François Rabelais publishes Pantagruel, the first to appear of his five books about the giant Pantagruel and his father Gargantua | |
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| 1532 |
| | | Pizarro and his tiny force ambush and massacre the Inca court in Cajamarca, capturing Atahualpa himself alive | |
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| 1532 |
| | | Atahualpa agrees to buy his freedom from the Spaniards with a room full of gold and another of silver | |
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